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Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

Aberrant regulation of the Wnt/β-catenin signaling pathway is one of the major causes of colorectal cancer (CRC). Loss-of-function mutations in APC are commonly found in CRC, leading to inappropriate activation of canonical Wnt signaling. Conversely, gain-of-function mutations in KRAS and BRAF genes...

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發表在:Oncogene
Main Authors: Lemieux, E, Cagnol, S, Beaudry, K, Carrier, J, Rivard, N
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687460/
https://ncbi.nlm.nih.gov/pubmed/25500543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.416
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