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Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

In Alzheimer Disease (AD), the mechanistic connection of the two major pathological hallmarks, namely deposition of Amyloid-beta (Aβ) in the form of extracellular plaques, and the pathological changes of the intracellular protein Tau (such as phosphorylation, missorting, aggregation), is not well un...

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Publicat a:Mol Neurodegener
Autors principals: Zempel, Hans, Mandelkow, Eva-Maria
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687341/
https://ncbi.nlm.nih.gov/pubmed/26691836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0064-1
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