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A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
Activation of the ERK pathway is a hallmark of cancer and targeting of upstream signalling partners led to the development of approved drugs. Recently SCH772984 has been shown to be a selective and potent ERK1/2 inhibitor. Here we report the structural mechanism for its remarkable selectivity. In ER...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687050/ https://ncbi.nlm.nih.gov/pubmed/25195011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1629 |
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