The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer’s Disease of humans and mice

The APOE4 allele confers greater risk of Alzheimer’s Disease (AD) for women than men, in conjunction with greater clinical deficits per unit of AD neuropathology (plaques, tangles). Cerebral microbleeds, which contribute to cognitive dysfunctions during AD, also show APOE4 excess, but sex-APOE allel...

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書誌詳細
出版年:Neurobiol Aging
主要な著者: Cacciottolo, Mafalda, Christensen, Amy, Moser, Alexandra, Liu, Jiahui, Pike, Christian J., Sullivan, Patrick M., Morgan, Todd E., Dolzhenko, Egor, Charidimou, Andreas, Wahlund, Lars-Olaf, Wiberg, Maria Kristofferson, Shams, Sara, Chiang, Gloria Chia-Yi, Finch, Caleb E.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687024/
https://ncbi.nlm.nih.gov/pubmed/26686669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.10.010
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