The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer’s Disease of humans and mice

The APOE4 allele confers greater risk of Alzheimer’s Disease (AD) for women than men, in conjunction with greater clinical deficits per unit of AD neuropathology (plaques, tangles). Cerebral microbleeds, which contribute to cognitive dysfunctions during AD, also show APOE4 excess, but sex-APOE allel...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Cacciottolo, Mafalda, Christensen, Amy, Moser, Alexandra, Liu, Jiahui, Pike, Christian J., Sullivan, Patrick M., Morgan, Todd E., Dolzhenko, Egor, Charidimou, Andreas, Wahlund, Lars-Olaf, Wiberg, Maria Kristofferson, Shams, Sara, Chiang, Gloria Chia-Yi, Finch, Caleb E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687024/
https://ncbi.nlm.nih.gov/pubmed/26686669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.10.010
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