The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer’s Disease of humans and mice

The APOE4 allele confers greater risk of Alzheimer’s Disease (AD) for women than men, in conjunction with greater clinical deficits per unit of AD neuropathology (plaques, tangles). Cerebral microbleeds, which contribute to cognitive dysfunctions during AD, also show APOE4 excess, but sex-APOE allel...

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發表在:Neurobiol Aging
Main Authors: Cacciottolo, Mafalda, Christensen, Amy, Moser, Alexandra, Liu, Jiahui, Pike, Christian J., Sullivan, Patrick M., Morgan, Todd E., Dolzhenko, Egor, Charidimou, Andreas, Wahlund, Lars-Olaf, Wiberg, Maria Kristofferson, Shams, Sara, Chiang, Gloria Chia-Yi, Finch, Caleb E.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687024/
https://ncbi.nlm.nih.gov/pubmed/26686669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.10.010
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