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Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

Mouse skin carcinomas arise from a small subpopulation of benign papillomas with an increased risk of malignant conversion. These papillomas arise with limited stimulation by tumor promoters, appear rapidly, and do not regress, suggesting that they differ in growth properties from the majority of be...

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Autores principales: Glick, A B, Kulkarni, A B, Tennenbaum, T, Hennings, H, Flanders, K C, O'Reilly, M, Sporn, M B, Karlsson, S, Yuspa, S H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC46870/
https://ncbi.nlm.nih.gov/pubmed/7687059
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