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HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface
The binding mechanism of HIV-1 protease monomers leading to the catalytically competent dimeric enzyme has been investigated by means of state-of-the-art atomistic simulations. The emerging picture allows a deeper understanding of experimental observations and reveals that water molecules trapped at...
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| I publikationen: | Sci Rep |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686983/ https://ncbi.nlm.nih.gov/pubmed/26692118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18555 |
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