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Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications
We present a remodeling method for high-affinity unnatural-base DNA aptamers to augment their thermal stability and nuclease resistance, for use as drug candidates targeting specific proteins. Introducing a unique mini-hairpin DNA provides robust stability to unnatural-base DNA aptamers generated by...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686876/ https://ncbi.nlm.nih.gov/pubmed/26690672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18478 |
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