Lataa...
Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications
We present a remodeling method for high-affinity unnatural-base DNA aptamers to augment their thermal stability and nuclease resistance, for use as drug candidates targeting specific proteins. Introducing a unique mini-hairpin DNA provides robust stability to unnatural-base DNA aptamers generated by...
Tallennettuna:
| Julkaisussa: | Sci Rep |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2015
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686876/ https://ncbi.nlm.nih.gov/pubmed/26690672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18478 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|