Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonists have emerged as treatment options for type 2 diabetes mellitus (T2DM). GLP-1R signals through G-protein-dependent, and G-protein-independent pathways by engaging the scaffold protein β-arrestin; preferential signalling of ligands through one...

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Publicado no:Nat Commun
Main Authors: Zhang, Hongkai, Sturchler, Emmanuel, Zhu, Jiang, Nieto, Ainhoa, Cistrone, Philip A., Xie, Jia, He, LinLing, Yea, Kyungmoo, Jones, Teresa, Turn, Rachel, Di Stefano, Peter S., Griffin, Patrick R., Dawson, Philip E., McDonald, Patricia H., Lerner, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686834/
https://ncbi.nlm.nih.gov/pubmed/26621478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9918
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