Disturbances of Ligand Potency and Enhanced Degradation of the Human Glycine Receptor at Affected Positions G160 and T162 Originally Identified in Patients Suffering from Hyperekplexia

Ligand-binding of Cys-loop receptors is determined by N-terminal extracellular loop structures from the plus as well as from the minus side of two adjacent subunits in the pentameric receptor complex. An aromatic residue in loop B of the glycine receptor (GlyR) undergoes direct interaction with the...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Atak, Sinem, Langlhofer, Georg, Schaefer, Natascha, Kessler, Denise, Meiselbach, Heike, Delto, Carolyn, Schindelin, Hermann, Villmann, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686643/
https://ncbi.nlm.nih.gov/pubmed/26733802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2015.00079
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