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The GlyR Extracellular β8–β9 Loop – A Functional Determinant of Agonist Potency

Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Janzen, Dieter, Schaefer, Natascha, Delto, Carolyn, Schindelin, Hermann, Villmann, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640878/
https://ncbi.nlm.nih.gov/pubmed/29062270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00322
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