Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis

BACKGROUND & AIMS: Multidrug resistance–associated protein 2 (MRP2) excretes conjugated organic anions including bilirubin and bile acids. Malfunction of MRP2 leads to jaundice in patients. Studies in rodents indicate that Radixin plays a critical role in determining Mrp2 canalicular membrane ex...

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Udgivet i:J Hepatol
Main Authors: Chai, Jin, Cai, Shi-Ying, Liu, Xiaocong, Lian, Wei, Chen, Sheng, Zhang, Liangjun, Feng, Xinchan, Cheng, Ying, He, Xiaochong, He, Yu, Chen, Lei, Wang, Rongquan, Wang, Huaizhi, Boyer, James L., Chen, Wensheng
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686151/
https://ncbi.nlm.nih.gov/pubmed/26212029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.07.016
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