Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction

BACKGROUND & AIMS: Levels of bile acid metabolic enzymes and membrane transporters have been reported to change in cholestasis. These alterations (e.g. CYP7A1 repression and MRP4 induction) are thought to be adaptive responses that attenuate cholestatic liver injury. However, the molecular mecha...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chai, Jin, Feng, Xinchan, Zhang, Liangjun, Chen, Sheng, Cheng, Ying, He, Xiaochong, Yang, Yingxue, He, Yu, Wang, Huaizhi, Wang, Rongquan, Chen, Wensheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370735/
https://ncbi.nlm.nih.gov/pubmed/25798860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120055
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