Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides

Pancreatic neuroendocrine tumours (pNETs) secreting proglucagon are associated with phenotypic heterogeneity. Here, we describe two patients with pNETs and varied clinical phenotypes due to differential processing and secretion of proglucagon-derived peptides (PGDPs). Case 1, a 57-year-old woman pre...

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Détails bibliographiques
Publié dans:Endocrinol Diabetes Metab Case Rep
Auteurs principaux: Challis, Benjamin G, Albrechtsen, Nicolai J Wewer, Bansiya, Vishakha, Burling, Keith, Barker, Peter, Hartmann, Bolette, Gribble, Fiona, O'Rahilly, Stephen, Holst, Jens J, Simpson, Helen L
Format: Artigo
Langue:Inglês
Publié: Bioscientifica Ltd 2015
Sujets:
Insight into Disease Pathogenesis or Mechanism of Therapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685488/
https://ncbi.nlm.nih.gov/pubmed/26693280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EDM-15-0105
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