Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides

Pancreatic neuroendocrine tumours (pNETs) secreting proglucagon are associated with phenotypic heterogeneity. Here, we describe two patients with pNETs and varied clinical phenotypes due to differential processing and secretion of proglucagon-derived peptides (PGDPs). Case 1, a 57-year-old woman pre...

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Veröffentlicht in:Endocrinol Diabetes Metab Case Rep
Hauptverfasser: Challis, Benjamin G, Albrechtsen, Nicolai J Wewer, Bansiya, Vishakha, Burling, Keith, Barker, Peter, Hartmann, Bolette, Gribble, Fiona, O'Rahilly, Stephen, Holst, Jens J, Simpson, Helen L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Bioscientifica Ltd 2015
Schlagworte:
Insight into Disease Pathogenesis or Mechanism of Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685488/
https://ncbi.nlm.nih.gov/pubmed/26693280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EDM-15-0105
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