Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides

Pancreatic neuroendocrine tumours (pNETs) secreting proglucagon are associated with phenotypic heterogeneity. Here, we describe two patients with pNETs and varied clinical phenotypes due to differential processing and secretion of proglucagon-derived peptides (PGDPs). Case 1, a 57-year-old woman pre...

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Detalles Bibliográficos
Publicado en:Endocrinol Diabetes Metab Case Rep
Main Authors: Challis, Benjamin G, Albrechtsen, Nicolai J Wewer, Bansiya, Vishakha, Burling, Keith, Barker, Peter, Hartmann, Bolette, Gribble, Fiona, O'Rahilly, Stephen, Holst, Jens J, Simpson, Helen L
Formato: Artigo
Idioma:Inglês
Publicado: Bioscientifica Ltd 2015
Assuntos:
Insight into Disease Pathogenesis or Mechanism of Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685488/
https://ncbi.nlm.nih.gov/pubmed/26693280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EDM-15-0105
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