Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides

Pancreatic neuroendocrine tumours (pNETs) secreting proglucagon are associated with phenotypic heterogeneity. Here, we describe two patients with pNETs and varied clinical phenotypes due to differential processing and secretion of proglucagon-derived peptides (PGDPs). Case 1, a 57-year-old woman pre...

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Dettagli Bibliografici
Pubblicato in:Endocrinol Diabetes Metab Case Rep
Autori principali: Challis, Benjamin G, Albrechtsen, Nicolai J Wewer, Bansiya, Vishakha, Burling, Keith, Barker, Peter, Hartmann, Bolette, Gribble, Fiona, O'Rahilly, Stephen, Holst, Jens J, Simpson, Helen L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bioscientifica Ltd 2015
Soggetti:
Insight into Disease Pathogenesis or Mechanism of Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685488/
https://ncbi.nlm.nih.gov/pubmed/26693280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EDM-15-0105
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