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G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation
Methylation of histone H3-lysine 9 (H3K9) and H3K27 by the methyltransferase G9a and polycomb repressive complex 2 (PRC2) inhibits transcription of target genes. A crosstalk between G9a and PRC2 via direct physical interaction has been shown recently. Here, we demonstrate an alternative mechanism by...
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| I publikationen: | Sci Rep |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4685317/ https://ncbi.nlm.nih.gov/pubmed/26688070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18709 |
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