Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B

Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction wi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMB Rep
Main Authors: Han, Arim, Chae, Yun-Cheol, Park, Jin Woo, Kim, Kee-Beom, Kim, Ji-Young, Seo, Sang-Beom
Format: Artigo
Jezik:Inglês
Izdano: Korean Society for Biochemistry and Molecular Biology 2015
Teme:
Research-Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577290/
https://ncbi.nlm.nih.gov/pubmed/25413303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2015.48.7.188
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