Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B

Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction wi...

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Detalhes bibliográficos
Publicado no:BMB Rep
Main Authors: Han, Arim, Chae, Yun-Cheol, Park, Jin Woo, Kim, Kee-Beom, Kim, Ji-Young, Seo, Sang-Beom
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research-Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577290/
https://ncbi.nlm.nih.gov/pubmed/25413303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2015.48.7.188
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