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The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates

In many drug delivery strategies, an inefficient transfer of macromolecules such as proteins and nucleic acids to the cytosol often occurs because of their endosomal entrapment. One of the methods to overcome this problem is photochemical internalization, which is achieved using a photosensitizer an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Ohtsuki, Takashi, Miki, Shunya, Kobayashi, Shouhei, Haraguchi, Tokuko, Nakata, Eiji, Hirakawa, Kazutaka, Sumita, Kensuke, Watanabe, Kazunori, Okazaki, Shigetoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685267/
https://ncbi.nlm.nih.gov/pubmed/26686907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18577
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