DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity

The DNA damage response (DDR) is activated upon DNA damage and prevents accumulation of mutations and chromosomal rearrangements, both driving carcinogenesis. Tumor cells often have defects in the DDR, which in combination with continuous cell proliferation are exploited by genotoxic cancer therapie...

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Publicado en:Mol Oncol
Autores principales: van Jaarsveld, Marijn T.M., Wouters, Maikel D., Boersma, Antonius W.M., Smid, Marcel, van IJcken, Wilfred F.J., Mathijssen, Ron H.J., Hoeijmakers, Jan H.J., Martens, John W.M., van Laere, Steven, Wiemer, Erik A.C., Pothof, Joris
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2013
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685152/
https://ncbi.nlm.nih.gov/pubmed/24462518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.12.011
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