DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity

The DNA damage response (DDR) is activated upon DNA damage and prevents accumulation of mutations and chromosomal rearrangements, both driving carcinogenesis. Tumor cells often have defects in the DDR, which in combination with continuous cell proliferation are exploited by genotoxic cancer therapie...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: van Jaarsveld, Marijn T.M., Wouters, Maikel D., Boersma, Antonius W.M., Smid, Marcel, van IJcken, Wilfred F.J., Mathijssen, Ron H.J., Hoeijmakers, Jan H.J., Martens, John W.M., van Laere, Steven, Wiemer, Erik A.C., Pothof, Joris
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685152/
https://ncbi.nlm.nih.gov/pubmed/24462518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.12.011
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