DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity

The DNA damage response (DDR) is activated upon DNA damage and prevents accumulation of mutations and chromosomal rearrangements, both driving carcinogenesis. Tumor cells often have defects in the DDR, which in combination with continuous cell proliferation are exploited by genotoxic cancer therapie...

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Publicat a:Mol Oncol
Autors principals: van Jaarsveld, Marijn T.M., Wouters, Maikel D., Boersma, Antonius W.M., Smid, Marcel, van IJcken, Wilfred F.J., Mathijssen, Ron H.J., Hoeijmakers, Jan H.J., Martens, John W.M., van Laere, Steven, Wiemer, Erik A.C., Pothof, Joris
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2013
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685152/
https://ncbi.nlm.nih.gov/pubmed/24462518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.12.011
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