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Helios controls a limited subset of regulatory T cell functions

A subpopulation (60–70%) of Foxp3(+) T regulatory (Treg) cells in both mouse and man express the transcription factor, Helios, but the role of Helios in Treg function is still unknown. In order to examine the function of Helios in Treg cells, we have generated Treg-specific Helios deficient mice. We...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Sebastian, Mathew, Lopez-Ocasio, Maria, Metidji, Amina, Rieder, Sadiye Amcaoglu, Shevach, Ethan M., Thornton, Angela M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685018/
https://ncbi.nlm.nih.gov/pubmed/26582951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501704
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