The mitochondrial phosphatase PGAM5 is dispensable for necroptosis but promotes inflammasome activation in macrophages

The cytokine IL-1β is intimately linked to many pathological inflammatory conditions. Mature IL-1β secretion requires cleavage by the inflammasome. Recent evidence indicates that many cell death signal adaptors have regulatory roles in inflammasome activity. These include the apoptosis inducers FADD...

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Publicat a:J Immunol
Autors principals: Moriwaki, Kenta, Luz, Nivea Farias, Balaji, Sakthi, De Rosa, Maria Jose, O’Donnell, Carey L., Gough, Peter J., Bertin, John, Welsh, Raymond M., Chan, Francis Ka-Ming
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684958/
https://ncbi.nlm.nih.gov/pubmed/26582950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501662
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