Protumoral TSP50 Regulates Macrophage Activities and Polarization via Production of TNF-α and IL-1β, and Activation of the NF-κB Signaling Pathway

Testes-specific protease 50 (TSP50) is abnormally overexpressed in many kinds of cancers and promotes cell proliferation and migration. However, whether TSP50 can influence the tumor microenvironment, especially the function of immune cells in the microenvironment, remains largely unknown. We demons...

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Bibliographic Details
Published in:PLoS One
Main Authors: Yang, Cheng, Zhang, Dong-Mei, Song, Zhen-Bo, Hou, Ya-Qin, Bao, Yong-Li, Sun, Lu-Guo, Yu, Chun-Lei, Li, Yu-Xin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684331/
https://ncbi.nlm.nih.gov/pubmed/26684869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145095
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