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Redox Regulation of NF-κB p50 and M1 Polarization in Microglia
Redox-signaling is implicated in deleterious microglial activation underlying CNS disease, but how ROS program aberrant microglial function is unknown. Here, the oxidation of NF-κB p50 to a free radical intermediate is identified as a marker of dysfunctional M1 (pro-inflammatory) polarization in mic...
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| 發表在: | Glia |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4322433/ https://ncbi.nlm.nih.gov/pubmed/25331559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22762 |
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