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Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons
Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal mitochondrial transport in peripheral nerves. To determine the effects of P301L tau...
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| Udgivet i: | Neurobiol Dis |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Academic Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684147/ https://ncbi.nlm.nih.gov/pubmed/26459111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.10.007 |
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