Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways

INTRODUCTION: Pilocytic astrocytomas are slow-growing tumors that usually occur in the cerebellum or in the midline along the hypothalamic/optic pathways. The most common genetic alterations in pilocytic astrocytomas activate the ERK/MAPK signal transduction pathway, which is a major driver of proli...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Jones, Tania A., Jeyapalan, Jennie N., Forshew, Tim, Tatevossian, Ruth G., Lawson, Andrew R. J., Patel, Sheena N., Doctor, Gabriel T., Mumin, Muhammad A., Picker, Simon R., Phipps, Kim P., Michalski, Antony, Jacques, Thomas S., Sheer, Denise
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683939/
https://ncbi.nlm.nih.gov/pubmed/26682910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0266-3
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