DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

Low-grade gliomas (LGGs) account for about a third of all brain tumours in children. We conducted a detailed study of DNA methylation and gene expression to improve our understanding of the biology of pilocytic and diffuse astrocytomas. Pilocytic astrocytomas were found to have a distinctive signatu...

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Publicado en:Acta Neuropathol Commun
Autores principales: Jeyapalan, Jennie N., Doctor, Gabriel T., Jones, Tania A., Alberman, Samuel N., Tep, Alexander, Haria, Chirag M., Schwalbe, Edward C., Morley, Isabel C. F., Hill, Alfred A., LeCain, Magdalena, Ottaviani, Diego, Clifford, Steven C., Qaddoumi, Ibrahim, Tatevossian, Ruth G., Ellison, David W., Sheer, Denise
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882864/
https://ncbi.nlm.nih.gov/pubmed/27229157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0323-6
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