Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

BACKGROUND: Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Wuhrer, Manfred, Selman, Maurice H. J., McDonnell, Liam A., Kümpfel, Tania, Derfuss, Tobias, Khademi, Mohsen, Olsson, Tomas, Hohlfeld, Reinhard, Meinl, Edgar, Krumbholz, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683913/
https://ncbi.nlm.nih.gov/pubmed/26683050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0450-1
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