Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration

Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk factors. Stress-induced premature cellular senescence (SIPS) is postulated to c...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Marazita, Mariela C., Dugour, Andrea, Marquioni-Ramella, Melisa D., Figueroa, Juan M., Suburo, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683426/
https://ncbi.nlm.nih.gov/pubmed/26654980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.11.011
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