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Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet
Fatty liver is associated with endoplasmic reticulum stress and activation of the hepatic unfolded protein response (UPR). Reduced hepatic expression of the UPR regulator X-box binding protein 1 spliced (XBP1s) is associated with human nonalcoholic steatohepatitis (NASH), and feeding mice a high-fat...
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| Udgivet i: | Am J Physiol Gastrointest Liver Physiol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4683298/ https://ncbi.nlm.nih.gov/pubmed/26472223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00132.2015 |
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