Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet

Fatty liver is associated with endoplasmic reticulum stress and activation of the hepatic unfolded protein response (UPR). Reduced hepatic expression of the UPR regulator X-box binding protein 1 spliced (XBP1s) is associated with human nonalcoholic steatohepatitis (NASH), and feeding mice a high-fat...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Liu, Xiaoying, Henkel, Anne S., LeCuyer, Brian E., Schipma, Matthew J., Anderson, Kristy A., Green, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Liver and Biliary Tract Physiology/Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683298/
https://ncbi.nlm.nih.gov/pubmed/26472223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00132.2015
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