Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression

Glial cell line-derived neurotrophic factor (GDNF) protects against high-fat diet (HFD)-induced hepatic steatosis in mice, however, the mechanisms involved are not known. In this study we investigated the effects of GDNF overexpression and nanoparticle delivery of GDNF in mice on hepatic steatosis a...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Mwangi, Simon Musyoka, Peng, Sophia, Nezami, Behtash Ghazi, Thorn, Natalie, Farris, Alton B., Jain, Sanjay, Laroui, Hamed, Merlin, Didier, Anania, Frank, Srinivasan, Shanthi
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Liver and Biliary Tract Physiology/Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719063/
https://ncbi.nlm.nih.gov/pubmed/26564715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00196.2015
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