Carboxyl-terminal Truncations of ClC-Kb Abolish Channel Activation by Barttin Via Modified Common Gating and Trafficking

ClC-K chloride channels are crucial for auditory transduction and urine concentration. Mutations in CLCNKB, the gene encoding the renal chloride channel hClC-Kb, cause Bartter syndrome type III, a human genetic condition characterized by polyuria, hypokalemia, and alkalosis. In recent years, several...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Stölting, Gabriel, Bungert-Plümke, Stefanie, Franzen, Arne, Fahlke, Christoph
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683263/
https://ncbi.nlm.nih.gov/pubmed/26453302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675827
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