Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury

Sirtuin 1 (SIRT1), an NAD(+)-dependent histone deacetylase, plays crucial roles in various biological processes including longevity, stress response, and cell survival. Endoplasmic reticulum (ER) stress is caused by dysfunction of ER homeostasis and exacerbates various diseases including diabetes, f...

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Publicado en:J Biol Chem
Autores principales: Koga, Tomoaki, Suico, Mary Ann, Shimasaki, Shogo, Watanabe, Eriko, Kai, Yukari, Koyama, Kosuke, Omachi, Kohei, Morino-Koga, Saori, Sato, Takashi, Shuto, Tsuyoshi, Mori, Kazutoshi, Hino, Shinjiro, Nakao, Mitsuyoshi, Kai, Hirofumi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683260/
https://ncbi.nlm.nih.gov/pubmed/26499802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664169
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