Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

We utilized induced pluripotent stem cells (iPSCs) derived from Huntington’s disease (HD) patients as a human model of HD and determined that the disease phenotypes only manifest in the differentiated neural stem cell (NSC) stage, not in iPSCs. To understand the molecular basis for the CAG repeat ex...

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Xehetasun bibliografikoak
Argitaratua izan da:Stem Cell Reports
Egile Nagusiak: Ring, Karen L., An, Mahru C., Zhang, Ningzhe, O’Brien, Robert N., Ramos, Eliana Marisa, Gao, Fuying, Atwood, Robert, Bailus, Barbara J., Melov, Simon, Mooney, Sean D., Coppola, Giovanni, Ellerby, Lisa M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682390/
https://ncbi.nlm.nih.gov/pubmed/26651603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.11.005
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