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A computational method for identification of vaccine targets from protein regions of conserved human leukocyte antigen binding

BACKGROUND: Computational methods for T cell-based vaccine target discovery focus on selection of highly conserved peptides identified across pathogen variants, followed by prediction of their binding of human leukocyte antigen molecules. However, experimental studies have shown that T cells often t...

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Bibliografische gegevens
Gepubliceerd in:BMC Med Genomics
Hoofdauteurs: Olsen, Lars R, Simon, Christian, Kudahl, Ulrich J, Bagger, Frederik O, Winther, Ole, Reinherz, Ellis L, Zhang, Guang L, Brusic, Vladimir
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682376/
https://ncbi.nlm.nih.gov/pubmed/26679766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-8-S4-S1
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