In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

BACKGROUND: We examined the anti-tumor effect and radiosensitizing potential of a small molecule inhibitor of fibroblast growth factor receptor (FGFR) in colorectal cancer (CRC) in vitro and in vivo. METHODS: Effects of in vitro drug treatment on cell survival, proliferation, FGFR signaling, cell cy...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Verstraete, Maud, Debucquoy, Annelies, Gonnissen, Annelies, Dok, Ruveyda, Isebaert, Sofie, Devos, Ellen, McBride, William, Haustermans, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682227/
https://ncbi.nlm.nih.gov/pubmed/26675289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-2000-8
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