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Use of functional polymorphisms to elucidate the peptide binding site of TAP complexes

The transporter associated with antigen processing (TAP) translocates peptides from the cytosol to the endoplasmic reticulum (ER) lumen to enable immune surveillance by CD8(+) T cells. Peptide transport is preceded by peptide binding to a cytosol-accessible surface of TAP1/TAP2 complexes, but the lo...

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Pubblicato in:J Immunol
Autori principali: Geng, Jie, Pogozheva, Irina D., Mosberg, Henry I., Raghavan, Malini
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681580/
https://ncbi.nlm.nih.gov/pubmed/26324772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500985
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