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Use of functional polymorphisms to elucidate the peptide binding site of TAP complexes

The transporter associated with antigen processing (TAP) translocates peptides from the cytosol to the endoplasmic reticulum (ER) lumen to enable immune surveillance by CD8(+) T cells. Peptide transport is preceded by peptide binding to a cytosol-accessible surface of TAP1/TAP2 complexes, but the lo...

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Publicado en:J Immunol
Main Authors: Geng, Jie, Pogozheva, Irina D., Mosberg, Henry I., Raghavan, Malini
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681580/
https://ncbi.nlm.nih.gov/pubmed/26324772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500985
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