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Shared Molecular Mechanisms in Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: Neurofilament-dependent Transport of sAPP, FUS, TDP-43, and SOD1, with Endoplasmic Reticulum-like Tubules
BACKGROUND: Amyotrophic lateral sclerosis (ALS), a debilitating neurodegenerative disorder of the motor neurons, leads to the disorganization of the neurofilament (NF) cytoskeleton, and – ultimately - the deterioration of the neuromuscular junction (NMJ). Some familial cases of ALS are caused by mut...
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| Udgivet i: | Neurodegener Dis |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4681536/ https://ncbi.nlm.nih.gov/pubmed/26605911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000439256 |
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