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Shared Molecular Mechanisms in Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: Neurofilament-dependent Transport of sAPP, FUS, TDP-43, and SOD1, with Endoplasmic Reticulum-like Tubules

BACKGROUND: Amyotrophic lateral sclerosis (ALS), a debilitating neurodegenerative disorder of the motor neurons, leads to the disorganization of the neurofilament (NF) cytoskeleton, and – ultimately - the deterioration of the neuromuscular junction (NMJ). Some familial cases of ALS are caused by mut...

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Bibliografiske detaljer
Udgivet i:Neurodegener Dis
Main Authors: Muresan, Virgil, Muresan, Zoia Ladescu
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681536/
https://ncbi.nlm.nih.gov/pubmed/26605911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000439256
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