Structures of the RNA polymerase-σ(54) reveal new and conserved regulatory strategies

Transcription by RNA polymerase in bacteria requires specific promoter recognition by σ factors. The major variant σ factor (σ(54)) initially forms a transcriptionally silent complex requiring specialised ATP-dependent activators for initiation. Our crystal structure of the 450 kDa RNAP-σ(54) holoen...

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Vydáno v:Science
Hlavní autoři: Yang, Yun, Darbari, Vidya C., Zhang, Nan, Lu, Duo, Glyde, Robert, Wang, Yiping, Winkelman, Jared, Gourse, Richard L., Murakami, Katsuhiko S., Buck, Martin, Zhang, Xiaodong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681505/
https://ncbi.nlm.nih.gov/pubmed/26293966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab1478
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