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Structures of the RNA polymerase-σ(54) reveal new and conserved regulatory strategies
Transcription by RNA polymerase in bacteria requires specific promoter recognition by σ factors. The major variant σ factor (σ(54)) initially forms a transcriptionally silent complex requiring specialised ATP-dependent activators for initiation. Our crystal structure of the 450 kDa RNAP-σ(54) holoen...
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| Pubblicato in: | Science |
|---|---|
| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4681505/ https://ncbi.nlm.nih.gov/pubmed/26293966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab1478 |
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