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Neuroprotective Role of Prostaglandin PGE(2) EP2 Receptor in Hemin-mediated Toxicity
Heme (Fe(2+) protoporphyrin IX) and hemin (Fe(3+)), the prosthetic group of hemoprotein, are cytotoxic due to their ability to contribute to the production of reactive oxygen species, increased intracellular calcium levels and stimulate glutamate mediated-excitotoxicity. Previous work by our group s...
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| 出版年: | Neurotoxicology |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4681391/ https://ncbi.nlm.nih.gov/pubmed/25451967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2014.10.012 |
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