Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

BACKGROUND: During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem molecules and interfering with their crystallization. In chloroquine-resistant stra...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Dambuza, Ntokozo S., Smith, Peter, Evans, Alicia, Norman, Jennifer, Taylor, Dale, Andayi, Andrew, Egan, Timothy, Chibale, Kelly, Wiesner, Lubbe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681141/
https://ncbi.nlm.nih.gov/pubmed/26671222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-1032-5
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