Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

BACKGROUND: During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem molecules and interfering with their crystallization. In chloroquine-resistant stra...

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Vydáno v:Malar J
Hlavní autoři: Dambuza, Ntokozo S., Smith, Peter, Evans, Alicia, Norman, Jennifer, Taylor, Dale, Andayi, Andrew, Egan, Timothy, Chibale, Kelly, Wiesner, Lubbe
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681141/
https://ncbi.nlm.nih.gov/pubmed/26671222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-1032-5
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