Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

BACKGROUND: Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized artemisinin-aminoquinoline hybrids were evaluated to ascertain whether the potent lo...

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Detalhes bibliográficos
Main Authors: Lombard, Marli C, N’Da, David D, Tran Van Ba, Christophe, Wein, Sharon, Norman, Jennifer, Wiesner, Lubbe, Vial, Henri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598976/
https://ncbi.nlm.nih.gov/pubmed/23433124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-71
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