Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart

Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A activity is requisite for cardiac excitation-contraction coupling and central in adrenergic signaling. We found that mice deficient in the PP2A re...

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Published in:Sci Signal
Main Authors: Little, Sean C., Curran, Jerry, Makara, Michael A., Kline, Crystal F., Ho, Hsiang-Ting, Xu, Zhaobin, Wu, Xiangqiong, Polina, Iuliia, Musa, Hassan, Meadows, Allison M., Carnes, Cynthia A., Biesiadecki, Brandon J., Davis, Jonathan P., Weisleder, Noah, Györke, Sandor, Wehrens, Xander H., Hund, Thomas J., Mohler, Peter J.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680974/
https://ncbi.nlm.nih.gov/pubmed/26198358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa5876
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