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Influence of Cardiopulmonary Bypass on the Interaction of Recombinant Factor VIIa with Activated Platelets

Recombinant factor VIIa (rFVIIa) interacts preferentially with coated platelets characterized by a high exposure of phosphatidyl serine (PS), FV, FVIII, FIX, and FX binding, and fibrinogen. Cardiopulmonary bypass (CPB) is known to impair platelet function. In this study, the influence of CPB on form...

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Detalhes bibliográficos
Publicado no:J Extra Corpor Technol
Main Authors: Kjalke, Marianne, Runge, Marx, Rojkjaer, Rasmus, Steinbruchel, Daniel, Johansson, Pär I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of ExtraCorporeal Technology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680214/
https://ncbi.nlm.nih.gov/pubmed/19681308
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