Targeted Deep Sequencing Identifies Rare ‘loss-of-function’ Variants in IFNGR1 for Risk of Atopic Dermatitis Complicated by Eczema Herpeticum

BACKGROUND: A subset of atopic dermatitis (AD) is associated with increased susceptibility to eczema herpeticum (ADEH+). We previously reported that common single nucleotide polymorphisms (SNPs) in interferon-gamma (IFNG) and receptor 1 (IFNGR1) were associated with ADEH+ phenotype. OBJECTIVE: To in...

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Publicado no:J Allergy Clin Immunol
Main Authors: Gao, Li, Bin, Lianghua, Rafaels, Nicholas M, Huang, Lili, Potee, Joseph, Ruczinski, Ingo, Beaty, Terri H., Paller, Amy S., Schneider, Lynda C., Gallo, Rich, Hanifin, Jon M., Beck, Lisa A., Geha, Raif S., Mathias, Rasika A., Barnes, Kathleen C., Leung, Donald Y. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679503/
https://ncbi.nlm.nih.gov/pubmed/26343451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.06.047
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