Targeted Deep Sequencing Identifies Rare ‘loss-of-function’ Variants in IFNGR1 for Risk of Atopic Dermatitis Complicated by Eczema Herpeticum

BACKGROUND: A subset of atopic dermatitis (AD) is associated with increased susceptibility to eczema herpeticum (ADEH+). We previously reported that common single nucleotide polymorphisms (SNPs) in interferon-gamma (IFNG) and receptor 1 (IFNGR1) were associated with ADEH+ phenotype. OBJECTIVE: To in...

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Détails bibliographiques
Publié dans:J Allergy Clin Immunol
Auteurs principaux: Gao, Li, Bin, Lianghua, Rafaels, Nicholas M, Huang, Lili, Potee, Joseph, Ruczinski, Ingo, Beaty, Terri H., Paller, Amy S., Schneider, Lynda C., Gallo, Rich, Hanifin, Jon M., Beck, Lisa A., Geha, Raif S., Mathias, Rasika A., Barnes, Kathleen C., Leung, Donald Y. M.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679503/
https://ncbi.nlm.nih.gov/pubmed/26343451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.06.047
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