Targeted Deep Sequencing Identifies Rare ‘loss-of-function’ Variants in IFNGR1 for Risk of Atopic Dermatitis Complicated by Eczema Herpeticum

BACKGROUND: A subset of atopic dermatitis (AD) is associated with increased susceptibility to eczema herpeticum (ADEH+). We previously reported that common single nucleotide polymorphisms (SNPs) in interferon-gamma (IFNG) and receptor 1 (IFNGR1) were associated with ADEH+ phenotype. OBJECTIVE: To in...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Gao, Li, Bin, Lianghua, Rafaels, Nicholas M, Huang, Lili, Potee, Joseph, Ruczinski, Ingo, Beaty, Terri H., Paller, Amy S., Schneider, Lynda C., Gallo, Rich, Hanifin, Jon M., Beck, Lisa A., Geha, Raif S., Mathias, Rasika A., Barnes, Kathleen C., Leung, Donald Y. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679503/
https://ncbi.nlm.nih.gov/pubmed/26343451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.06.047
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