Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection

Human SAMHD1 (hSAMHD1) restricts HIV-1 infection in non-dividing cells by depleting intracellular dNTPs to limit viral reverse transcription. Phosphorylation of hSAMHD1 at threonine (T) 592 by cyclin-dependent kinase (CDK) 1 and CDK2 negatively regulates HIV-1 restriction. Mouse SAMHD1 (mSAMHD1) res...

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Publicado en:Virology
Main Authors: Wang, Feifei, St. Gelais, Corine, de Silva, Suresh, Zhang, Hong, Geng, Yu, Shepard, Caitlin, Kim, Baek, Yount, Jacob S., Wu, Li
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679491/
https://ncbi.nlm.nih.gov/pubmed/26580513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.10.024
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